Wednesday 13 April, 11:30 to 17:30 – Thursday 14 April, 8:30 to 12:00
|Cecília Rodrigues, Portugal|
|Robert Schwabe, United States|
|António Zorzano, Spain|
The Basic Science Seminar will provide an overview of the rapid scientific advances in the growing field of the gut-liver axis.
There has been a dramatic increase in our understanding of how the gut microbiome affects liver physiology and pathophysiology. Recent studies have revealed a key role of the gut microbiome in hepatic metabolism, immune responses, drug metabolism and carcinogenesis, thereby contributing to the development of fatty liver disease, fibrosis and hepatocellular carcinoma (HCC).
This Basic Science Seminar will provide detailed, high quality, in-depth examination of the different yet related aspects of gut-liver physiology, immunity and metabolism. The first half of this program will focus on fundamental biology of the microbiome, and functional links with the liver. The second half will provide a unique opportunity to focus on the basic molecular mechanisms of disease, biomarkers and novel therapeutics.
The microbiome represents a key factor and potential therapeutic target throughout different stages of multiple liver diseases. Knowledge about interactions between the gut microbiota and the liver will not only provide better understanding of the underlying pathophysiology, but also provides novel diagnostic and therapeutic opportunities. You will benefit from a wide representation of the topic by experts in microbiology, computational biology and specific liver diseases, including NASH, fibrosis and HCC.
The goal is to facilitate the understanding by which mechanisms of the microbiota modulate host physiologic processes and increase our comprehension of how an altered gut-liver axis contributes to health and disease in humans. Application of a systems biology approach to decipher molecular mechanisms underlying diseases influenced by the gut-liver axis presents a unique opportunity to develop novel therapies that sustain health in a personalized manner. In addition, the broad representation of speakers from diverse areas, such as immunology, metabolism, and physiology is likely to foster new collaborations.